THE REORGANIZATION OF THE NEUROMUSCULAR SYSTEM DURING AGEING: INFLUENCE OF REGULAR PHYSICAL ACTIVITY

Senescence is accompanied by various changes affecting the neuromuscular system that contribute to the decline in functional performances observed in elderly individuals. In addition to a profound remodelling of the neuromuscular system, several mechanisms located at both muscular and neural levels contribute to this lost of performances. Hopefully, regular physical activity may counteract or reverse some of the alterations encountered in old age. The purpose of this keynote lecture is to give an overview of the main age-related changes of the neuromuscular system and to evoke the potential influence of regular physical activity in limiting these alterations

Maximal discharge rate of motor units determines the maximal rate of force development during ballistic contractions in human

Journal ArticleSCOPUS: ar.jinfo:eu-repo/semantics/publishe

New Mathematical approaches in Electrocardiography Imaging inverse problem

International audienceImprove ECGI inverse problem reconstruction Introduce new mathematical approches to the field of the ECGI inverse problem Compare the performance of the new mathematical approaches to the state-of-the-art methods, mainly the MFS method used in commercial devices. In silico validation of the new approches. Assessment of some simplification hypothesis: Torso inhomogeneity Propose some uncertainty quantification apronches to deal with measurements errors Context and objectives Optimal control approach Mathematical model In silico gold standard Results Torso Heterogeneity effect Conclusions Forward model If we know the heart potential we can compute the electrical potential Inverse problem If we know the electrical potential and the current density at the outer boundary of the torso and we look for the electrical potential at the heart surface Computational heart and torso anatomical models + electrodes position Computational torso meshes: 250 nodes mesh (blue). More accurate FE mesh with 6400 nodes (green) Remarks Introducing the torso heterogeneity is natural with FEM. also anisotropy could be introduced The error is more important in the left ventricle Main results and perspectives New mathematical approches for solving the inverse problem in electrocardiography imaging based on optimal control Over all the 20 cases used in this study the optimal control method performs better than the MFS both in terms of relative error and correlation coefficient: Acknowledgment: This work was partially supported by an ANR grant part of "Investissements d'Avenir" program with reference ANR-10-IAHU-04. It is also supported by the LIRIMA international lab thought the EPICARD tea

Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases

Letter to the Edito

Effet du sorbothane sur l'amortissement des forces d'impact lors de la course

info:eu-repo/semantics/publishe